periplakin; 195 kD cornified envelope protein; 190 kD paraneoplastic pemphigus antigen (PPL, KIAA0568)

Function: - component of the cornified envelope of keratinocytes - may link the cornified envelope to desmosomes & intermediate filaments - may act as a localization signal in PKB/AKT-mediated signaling - homodimer or a heterodimer with envoplakin (EVPL) - interacts with PPHLN1 & VIM - binds to the PH domain of AKT1 - interacts with FCGR1A Structure: - belongs to the plakin or cytolinker family - contains 2 plectin repeats - contains 4 spectrin repeats Compartment: - cell junction, desmosome - cytoplasm, cytoskeleton - cell membrane (putative) - nucleus - mitochondrion (putative) - associated with desmosomes & intermediate filaments Expression: - expressed in stratified squamous epithelia & in some other epithelia - expressed during differentiation of epidermal keratinocytes

Related

desmosome intermediate filament keratinocyte

General

antigen cytoskeletal protein oligomerizing protein phosphoprotein

Properties

SIZE: entity length = 1756 aa MW = 205 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S14} coiled coil {16-125} coiled coil {188-389} MOTIF: spectrin repeat {216-317} spectrin repeat {323-485} spectrin repeat {505-612} coiled coil {585-820} spectrin repeat {733-861} coiled coil {886-1645} MOTIF: Ser phosphorylation site {S1331} Thr phosphorylation site {T1579} Plectin {1651-1685} MOTIF: Ser phosphorylation site {S1657} Plectin {1700-1735}

Database Correlations

OMIM 602871 UniProt O60437 Pfam PF00681 Entrez Gene 5493 Kegg hsa:5493

References

UniProt :accession Q92817