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translocator protein; peripheral-type benzodiazepine receptor; PBR; PKBS; mitochondrial benzodiazepine receptor (TSPO, BZRP, MBR)
Function:
- distinct from allosteric benzodiazepine site on GABA-A receptor
- most likely to comprise binding domains for benzodiazepines & isoquinoline carboxamides
- promotes production of GABA-A receptors [3]
- may play a role in the transport of porphyrins & heme
- role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (putative)
- interacts with BZRAP1 (putative)
- may interact with STAR (putative)
- interacts with MOST-1
Structure: belongs to the TspO/BZRP family
Compartment: mitochondrial membrane
Pharmacology:
- binds novel anxiolytic XBD173 [3]
General
mitochondrial membrane protein
receptor
transmembrane 5 protein
Properties
SIZE: entity length = 169 aa
MW = 19 kD
COMPARTMENT: outer mitochondrial membrane
MOTIF: transmembrane domain {6-26}
transmembrane domain {47-67}
transmembrane domain {80-100}
transmembrane domain {106-126}
transmembrane domain {135-155}
Database Correlations
OMIM 109610
UniProt P30536
Pfam PF03073
Entrez Gene 706
Kegg hsa:706
References
- UniProt :accession P30536
- NIEHS-SNPs
http://egp.gs.washington.edu/data/bzrp/
- Rupprecht R et al
Translocator protein (18 kD) as target for anxiolytics
without benzodiazepine-like side effects.
Science 2009 Jul 24; 325:490.
PMID: 19541954