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periostin (PN, osteoblast-specific factor 2, OSF-2, POSTN, OSF2)
Function:
1) binds to heparin
2) induces cell attachment & spreading
3) role in cell adhesion
Structure:
- contains 1 EMI domain.
- contains 4 FAS1 domains
Compartment: secreted, extracellular matrix
Alternative splicing: named isoforms=3
Expression:
- widely expressed
- highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, breast
Pathology:
1) up-regulated in epithelial ovarian tumors
- not expressed normal ovaries
2) highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor
3) overexpressed in breast cancers
- malignant breast cancer stem cells induce fibroblasts in organs of metastases to produce periostin [2]
General
glycoprotein
secreted protein
Properties
SIZE: MW = 93 kD
entity length = 836 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
EMI {40-94}
MOTIF: cysteine residue {C44}
MODIFICATION: cysteine residue {C80}
cysteine residue {C60}
MODIFICATION: cysteine residue {C69}
cysteine residue {C69}
MODIFICATION: cysteine residue {C60}
cysteine residue {C79}
MODIFICATION: cysteine residue {C92}
cysteine residue {C80}
MODIFICATION: cysteine residue {C44}
cysteine residue {C92}
MODIFICATION: cysteine residue {C79}
S1 domain {97-230}
S1 domain {234-365}
S1 domain {368-492}
S1 domain {496-628}
MOTIF: N-glycosylation site {N599}
Database Correlations
OMIM 608777
UniProt Q15063
PFAM correlations
References
- UniProt :accession Q15063
- Malanchi I et al.
Interactions between cancer stem cells and their niche govern
metastatic colonization.
Nature 2011 Dec 7; 481:85.
PMID: 22158103