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perhexiline
Indications:
- exertional angina pectoris
Adverse effects:
- neuropathy, hepatitis
Laboratory:
- perhexiline in serum/plasma
Mechanism of action:
- inhibits carnitine palmitoyltransferase (CPT-1 & CPT-2
- shifts myocardial substrate utilisation from long chain fatty acids to carbohydrates through inhibition of CPT-1 &, to a lesser extent, CPT-2
- results in increased glucose & lactate utilization & in increased ATP production for the same O2 consumption
Interactions
drug adverse effects of antihypertensive agents
General
vasodilator agent
amine
Database Correlations
PUBCHEM correlations
References
PubChem: 4746