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perfluorohexyloctane (Miebo)
Indications:
- used as an internal tamponade agent in surgery for complicated retinal detachments [1]
- treatment of dry eyes [2]
Dosage:
Solution: 1 g/mL
Mechanism of action:
- liquid semifluorinated alkane that is heavier than water [1]
- increases tear film thickness & lipid layer thickness in dry eye syndrome
- prevents evaporation of tears through stabilization of the lipid layer [2]
General
ophthalmic agent (eyedrops)
fluorocarbon
Database Correlations
PUBCHEM cid=10477896
References
- Kirchhof B, Wong D, Van Meurs J et al
Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated
retinal detachment surgery.
Am J Ophthalmol. 2002. 01/01
PMID: 11755844
- Schmidl D, Bata AM, Szegedi S et al
Influence of Perfluorohexyloctane Eye Drops on Tear Film Thickness in Patients with
Mild to Moderate Dry Eye Disease: A Randomized Controlled Clinical Trial.
J Ocul Pharmacol Ther. 2020 Apr;36(3):154-161
PMID: 31895638