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peregrin; bromodomain & PHD finger-containing protein 1; protein Br140 (BRPF1, BR140)
Function:
- component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity
- positively regulates the transcription of RUNX1 & RUNX2
- acetylated by MYST3
Structure:
- contains 1 bromo domain
- contains 1 C2H2-type Zn+2 finger
- contains 1 PHD-type Zn+2 finger
- contains 1 PWWP domain
Compartment:
- nucleus, cytoplasm
- localization to the nucleus depends on MYST3, ING5 & MEAF6
Alternative splicing: named isoforms=4
Expression: high levels in testis
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 1214 aa
MW = 137 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 21-47
EFFECTOR-BOUND: Zn+2
MYST3/MYST4 interaction {59-222}
MOTIF: Ser phosphorylation site {S120}
Ser phosphorylation site {S238}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 273-323
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 386-400
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S460}
Ser phosphorylation site {S462}
MEAF6/ING5 interaction {501-821}
transcriptional activation domain
SITE: 543-1079
MOTIF: bromodomain {645-715}
Ser phosphorylation site {S922}
Ser phosphorylation site {S1076}
PWWP domain {1085-1168}
Ser phosphorylation site {S1187}
Database Correlations
OMIM 602410
UniProt P55201
PFAM correlations
Entrez Gene 7862
Kegg hsa:7862
References
UniProt :accession P55201