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PER977

Indications: - potentially useful for treating hemorrage associated with use of direct oral anticoagulants (factor Xa inhibitors) [1] * fresh-frozen plasma & prothrombin complex may also be useful in this context Adverse effects: - minimal [1] Mechanism of action: - binds to all of the new oral anticoagulants & heparin & inhibits their anticoagulant activity [1]

General

antidote

References

  1. Ansell JE et al Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban. N Engl J Med. November 5, 2014. PMID: 25371966 http://www.nejm.org/doi/full/10.1056/NEJMc1411800