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peptidyl-tRNA hydrolase 2, mitochondrial (PTH-2, Bcl-2 inhibitor of transcription 1, PTRH2, BIT1, PTH2, CGI-147)
Function:
- natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis
- promotes caspase-independent apoptosis by regulating function of 2 transcriptional regulators, AES & TLE1
N-substituted aminoacyl-tRNA + H2O N-substituted amino acid + tRNA
Structure:
- monomer
- belongs to the PTH2 family
Compartment: mitochondrion
General
hydrolase
mitochondrial protein
Properties
SIZE: MW = 19 kD
entity length = 179 aa
COMPARTMENT: mitochondria
MOTIF: active site
Database Correlations
OMIM 608625
UniProt Q9Y3E5
Pfam PF01981
ENZYME 3.1.1.29
References
UniProt :accession Q9Y3E5