mitochondrial peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; peptide Met(O) reductase; protein-methionine-S-oxide reductase; PMSR (MSRA)

Function: - role as a repair enzyme for proteins that have been inactivated by oxidation - catalyzes reversible oxidation-reduction of methionine sulfoxide in proteins to methionine peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (S)-S-oxide + thioredoxin L-methionine + thioredoxin disulfide + H₂O = L-methionine (S)-S-oxide + thioredoxin Structure: - belongs to the MsrA Met sulfoxide reductase family Compartment: - isoform 1: mitochondrion - isoform 2: cytoplasm - isoform 3: cytoplasm, nucleus Alternative promoter usage: - isoforms 2 & 3 produced by alternative promoter usage Alternative splicing: - isoform 1 produced by alternative splicing Expression: - ubiquitous - expressed in adult kidney & cerebellum > liver, heart ventricles, bone marrow & hippocampus

Properties

SIZE: entity length = 235 aa MW = 26 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: active site

Database Correlations

OMIM 601250 UniProt Q9UJ68 Pfam PF01625 Entrez Gene 4482 Kegg hsa:4482 ENZYME 1.8.4.1

References

UniProt :accession Q9UJ68