peptidase inhibitor 16 (cysteine-rich secretory protein 9, CRISP-9, PSP94-binding protein, PI16, CRISP9, PSPBP, UNQ289/PRO328)

Function: - serine protease inhibitor (putative) - interacts with PSP94/MSMB Structure: - N-glycosylated - belongs to the CRISP family Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed in prostate, testis, ovary, intestine Pathology: - concentrates in prostate cencer patient's sera - may serve as a marker following prostatectomy for prostate cancer

General

enzyme inhibitor glycoprotein membrane protein

Properties

SIZE: MW = 49 kD entity length = 463 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-27} N-glycosylation site {N114} N-glycosylation site {N403} N-glycosylation site {N409} transmembrane domain {443-462}

Database Correlations

UniProt Q6UXB8 Pfam PF00188

References

UniProt :accession Q6UXB8