Pecanex-like protein 2 (PCNX2, PCNXL2, KIAA0435)

Structure: belongs to the pecanex family Compartment: membrane (putative) Alternative splicing: named isoforms=4 Pathology: - may play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H) Genetics: - PCNXL2 is characterized by high mutational frequencies & biallelic mutations in MSI-H colorectal tumors, & is thus likely to be a target gene in these tumors

General

glycoprotein human longevity protein transmembrane 15 protein

Properties

SIZE: entity length = 2137 aa MW = 237 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-33} transmembrane domain {34-54} cytoplasmic loop {56-56} transmembrane domain {57-77} exoplasmic loop {78-843} MOTIF: N-glycosylation site {N136} N-glycosylation site {N449} N-glycosylation site {N550} N-glycosylation site {N572} N-glycosylation site {N587} N-glycosylation site {N598} N-glycosylation site {N613} transmembrane domain {844-864} cytoplasmic loop {865-867} transmembrane domain {868-888} exoplasmic loop {889-900} transmembrane domain {901-921} cytoplasmic loop {922-951} transmembrane domain {952-972} exoplasmic loop {973-982} transmembrane domain {983-1003} cytoplasmic loop {1004-1028} transmembrane domain {1029-1049} exoplasmic loop {1050-1098} transmembrane domain {1099-1119} cytoplasmic loop {1120-1123} transmembrane domain {1124-1144} exoplasmic loop {1145-1192} transmembrane domain {1193-1213} cytoplasmic loop {1214-1236} transmembrane domain {1237-1257} exoplasmic loop {1258-1264} transmembrane domain {1265-1285} cytoplasmic loop {1286-1301} transmembrane domain {1302-1322} exoplasmic loop {1323-1323} transmembrane domain {1324-1344} cytoplasmic domain {1345-2137} MOTIF: N-glycosylation site {N1412} N-glycosylation site {N1553} N-glycosylation site {N1818} serine-rich region {1937-2063} MOTIF: serine residue (SEVERAL) N-glycosylation site {N2054}

Database Correlations

UniProt A6NKB5 Pfam PF05041 Entrez Gene 80003 Kegg hsa:80003

References

UniProt :accession A6NKB5