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PDZ domain containing protein 2 (activated in prostate cancer protein, AIPC, KIAA0300, PDZD2)
Function:
- interacts with SCN10A, CTNND2 & PKP4
Compartment:
- nucleus, endoplasmic reticulum, cytoplasm
- at cell-cell contacts in lung epithelial cells
- the proteolytic processed protein is secreted
Alternative splicing: named isoforms=2
Expression: expressed in prostate
Pathology:
- early promotion of prostate cancer (putative)
Related
PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain
PDZ domain-containing protein
General
nuclear protein
Properties
SIZE: MW = 302 kD
entity length = 2839 aa
COMPARTMENT: cytoplasm
cell nucleus
endoplasmic reticulum
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 85-182
PDZ domain
NAME: PDZ domain
SITE: 334-419
PDZ domain
NAME: PDZ domain
SITE: 586-672
PDZ domain
NAME: PDZ domain
SITE: 728-813
serine-rich region {2139-2194}
MOTIF: serine residue (SEVERAL)
proteolytic site {2492-2493}
PDZ domain
NAME: PDZ domain
SITE: 2622-2706
PDZ domain
NAME: PDZ domain
SITE: 2750-2835
Database Correlations
UniProt O15018
Pfam PF00595
References
UniProt :accession O15018