PDZ domain-containing protein 1 selections

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PDZ domain-containing protein 1 (CFTR-associated protein of 70 kD, Na+/Pi cotransporter C-terminal-associated protein, Na+Pi-Cap1, Na+/H+ exchanger regulatory factor 3, C-terminal linking & modulating protein, CLAMP, PDZK1, CAP70, NHERF3, PDZD1)

Function: 1) scaffold protein, connects plasma membrane proteins with regulatory components 2) regulates surface expression of plasma membrane proteins in epithelial cells apical domains 3) ion transport & second messenger cascades 4) forms complex with SLC9A3R1 5) clusters proteins, modulates trafficking & activity of associated membrane proteins 6) multidrug resistance via interaction with ABCC2 & PDZK1IP1 7) potentiates CFTR chloride channel activity (putative) 8) intracellular cholesterol transport &/or metabolism via SCARB1 (putative) 9) regulation of proximal tubular Na⁺-dependent inorganic phosphate cotransport 10) interacts with PDZK1IP1 & ABCC2 11) binds to the C-terminal region of SLC26A3 12) interacts via 1ST PDZ domain with C-terminal domain of SCARB1 13) interacts with AKAP2, BCR, CFTR, SLCO1A1, SLC22A12, SLC22A4, SLC22A5, SLC26A6, SLC9A3R2, SLC17A1 (putative) Compartment: - cytoplasm, peripheral membrane - apical compartment of proximal tubular cells - sinusoidal liver membranes Expression: - limited to epithelial cells - expressed in the kidney (brush border of proximal tubule), pancreas, liver, small intestine > adrenal cortex, testis, stomach Pathology: - overexpressed in breast carcinoma, renal carcinoma, lung carcinoma

cystic fibrosis transmembrane conductance regulator; CFTR; cAMP-dependent chloride channel; ATP-binding cassette transporter sub-family C member 7 (CFTR ABCC7) PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain PDZ domain-containing protein

General

secreted protein

Properties

SIZE: MW = 57 kD entity length = 519 aa COMPARTMENT: extracellular compartment MOTIF: PDZ domain NAME: PDZ domain SITE: 9-90 PDZ domain NAME: PDZ domain SITE: 134-215 PDZ domain NAME: PDZ domain SITE: 243-323 PDZ domain NAME: PDZ domain SITE: 378-458

Database Correlations

OMIM 603831 UniProt Q5T2W1 Pfam PF00595

References

UniProt :accession Q5T2W1