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PDZ & LIM domain protein 3 (actinin-associated LIM protein, alpha-actinin-2-associated LIM protein, PDLIM3, ALP)
Function:
1) role in the organization of actin filament arrays within muscle cells (putative)
2) interacts with ACTN2
Structure:
- contains 1 LIM zinc-binding domain
- contains 1 PDZ (DHR) domain
Compartment:
- localizes to myofiber Z-lines
Alternative splicing: named isoforms=3
Expression:
1) isoform 1 is highly expressed in differentiated skeletal muscle
2) isoform 2 is heart-specific
General
PDZ & LIM domain protein
Properties
SIZE: MW = 39 kD
entity length = 364 aa
COMPARTMENT: cytoplasm
MOTIF: PDZ domain
NAME: PDZ domain
SITE: 1-84
LIM domain {292-351}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
OMIM 605889
UniProt Q53GG5
PFAM correlations
References
UniProt :accession Q53GG5