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platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide (PDGFA, PDGF1)
Function:
- growth factor
- role in regulation of embryonic development, cell proliferation, cell migration, cell survival & chemotaxis
- potent mitogen for cells of mesenchymal origin
- required for
- normal lung alveolar septum formation during embryogenesis
- normal development of the GI tract
- normal development of Leydig cells
- spermatogenesis
- normal oligodendrocyte development
- normal myelination in the spinal cord & cerebellum
- role in wound healing
- may provide neuronal signal for glial differentiation in CNS
- signaling is modulated by the formation of heterodimers with PDGFB (putative)
- homodimer; antiparallel disulfide-linked dimer
- heterodimer with PDGFB; antiparallel disulfide-linked dimer
- the PDGFA homodimer interacts with PDGFRA homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- the heterodimer composed of PDGFA & PDGFB interacts with PDGFRA homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- interacts with CSPG4
Structure:
- the long form contains a basic insert which acts as a cell retention signal
- belongs to the PDGF/VEGF growth factor family
Compartment:
- secreted
- released by platelets upon wounding
Alternative splicing: named isoforms=2; long, short
Expression: platelets
General
glycoprotein
oligomerizing protein
platelet-derived growth factor (PDGF)
Properties
CONFIGURATION: dimer
SIZE: entity length = 211 aa
MW = 24 kD
COMPARTMENT: extracellular compartment
WITHIN: nervous system
MOTIF: signal sequence {1-20}
cysteine residue {C96}
MODIFICATION: cysteine residue {C140}
cysteine residue {C123}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C129}
MODIFICATION: cysteine residue {C177}
cysteine residue {C132}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C133}
MODIFICATION: cysteine residue {C179}
N-glycosylation site {N134}
cysteine residue {C140}
MODIFICATION: cysteine residue {C96}
Receptor binding site {158-162}
cysteine residue {C177}
MODIFICATION: cysteine residue {C129}
cysteine residue {C179}
MODIFICATION: cysteine residue {C133}
SECRETED-BY: neuron
platelet
macrophage
endothelial cell
smooth muscle
Database Correlations
OMIM 173430
UniProt P04085
PFAM correlations
Entrez Gene 5154
Kegg hsa:5154
References
- UniProt :accession P04085
- R&D systems' cytokine mini-reviews: PDGF
http://www.rndsystems.com/molecule_detail.aspx?m=1967
- Matsui T et al,
Isolation of a novel receptor cDNA establishes the existence of
two PDGF receptor genes
Science 243:800 1989
PMID: 2536956
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
Component-of
platelet-derived growth factor alpha/beta; PDGF-alpha/beta (PDGFA/PDGFB)