Search
PCNA-associated factor; hepatitis C virus NS5A-transactivated protein 9; HCV NS5A-transactivated protein 9; overexpressed in anaplastic thyroid carcinoma 1; OEATC-1; p15PAF (KIAA0101, NS5ATP9, PAF, L5)
Function:
1) protection of cells from UV-induced cell death
2) interacts with PCNA & isoform 2/p33ING1b of ING1
3) UV irradiation enhances interaction with PCNA & increases nuclear localization
Compartment: nucleus, mitochondrion
Expression:
- expressed predominantly in liver, pancreas, placenta
- not detected in heart, brain
- induced by UV irradiation
Pathology:
- highly expressed in a number of tumors
a) esophageal tumors
b) anaplastic thyroid carcinoma
c) non-small-cell lung cancer lines
Related
proliferating cell nuclear antigen (PCNA)
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 111 aa
MW = 12 kD
COMPARTMENT: mitochondria
cell nucleus
MOTIF: Ser phosphorylation site {S72}
Database Correlations
OMIM 610696
UniProt Q15004
Entrez Gene 9768
Kegg hsa:9768
References
UniProt :accession Q15004