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PC4 & SFRS1-interacting protein; CLL-associated antigen KW-7; dense fine speckles 70 kD protein; DFS 70; Lens epithelium-derived growth factor; transcriptional coactivator p75/p52 (PSIP1, DFS70, LEDGF, PSIP2)
Function:
- transcriptional coactivator
- neuroepithelial stem cell differentiation & neurogenesis
- lens epithelial cell gene regulation & stress responses
- role in lens epithelial to fiber cell terminal differentiation
- protective role during stress-induced apoptosis (putative)
- interacts with IFRD1
- isoform 1
- interacts POGZ & CDCA7L
- interacts with lentiviral & HIV-1 integrase & acts as a chromatin tethering factor to the chromosomal DNA
- interacts also with HIV-2 integrase
- isoform 2
- more general & stronger transcriptional coactivator.
- may also act as an adapter to coordinate pre-mRNA splicing
- interacts with SFRS1
- cellular cofactor for lentiviral integration
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with IFRD1/PC4
Structure:
- monomer
- residues 340-417 are necessary & sufficient for the interaction with HIV-1 IN (IBD domain)
- belongs to the HDGF family
- contains 1 PWWP domain
Compartment:
- nucleus
- chromatin-associated throughout the cell cycle
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- expressed in neurons, but not astrocytes
- elevated in fetal compared to adult brain
- in the adult brain, expressed in the subventricular zone, hippocampus, & undetectable elsewhere
Pathology:
- chromosomal translocation t(9;11)(p22;p15) involving PSIP1 with NUP98 is associated with childhood acute myeloid leukemia
General
phosphoprotein
transcriptional adaptor protein; transcriptional coactivator
Properties
SIZE: entity length = 530 aa
MW = 60 kD
COMPARTMENT: cell nucleus
MOTIF: PWWP domain {1-64}
Ser phosphorylation site {S105}
Ser phosphorylation site {S106}
Thr phosphorylation site {T122}
Ser phosphorylation site {S129}
Thr phosphorylation site {T134}
Thr phosphorylation site {T141}
nuclear translocation signal {146-156}
Thr phosphorylation site {T167}
Ser phosphorylation site {S177}
Thr phosphorylation site {T270}
Ser phosphorylation site {S271}
Thr phosphorylation site {T272}
Ser phosphorylation site {S273}
Ser phosphorylation site {S275}
coiled coil {306-334}
coiled coil {371-395}
Ser phosphorylation site {S434}
Thr phosphorylation site {T437}
Ser phosphorylation site {S443}
Ser phosphorylation site {S522}
Thr phosphorylation site {T527}
Database Correlations
OMIM 603620
UniProt O75475
PFAM correlations
Entrez Gene 11168
Kegg hsa:11168
References
- UniProt :accession O75475
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/PSIP1ID405ch9q22.html