PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein, PAXIP1, PAXIP1L, PTIP, CAGF28)

Function: - component of DNA damage response - phosphoserine or phosphothreonine-specific binding - recognizes substrates phosphorylated by the kinases ATM & ATR, in response to gamma irradiation - role in PAX2-dependent transcriptional regulation (putative) - role in early development, most probably in cell proliferation - interacts with the C-terminal transactivation domain of PAX2 (putative) Structure: - BRCT domains function as a single module & are necessary & sufficient for phospho-specific binding - contains 5 BRCT domains Compartment: nucleus, matrix side (putative) Alternative splicing: named isoforms=5

Properties

SIZE: entity length = 1035 aa MW = 118 kD COMPARTMENT: cell nucleus MOTIF: BRCA1 C-terminal (BRCT) motif SITE: 59-149 glutamate-rich region {155-182} MOTIF: glutamate residue (SEVERAL) glutamine-rich region {338-556} MOTIF: glutamine residue (SEVERAL) BRCA1 C-terminal (BRCT) motif SITE: 567-660 MOTIF: nuclear translocation signal {634-651} BRCA1 C-terminal (BRCT) motif SITE: 667-755 BRCA1 C-terminal (BRCT) motif SITE: 832-913 BRCA1 C-terminal (BRCT) motif SITE: 934-975

Database Correlations

OMIM 608254 UniProt Q6ZW49 Pfam PF00533

References

UniProt :accession Q6ZW49