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pathologic mechanisms in Alzheimer's disease
General
pathologic process
Database Correlations
Entrez Gene 378483
References
- Delacourte A.
The natural and molecular history of Alzheimer's disease.
J Alzheimers Dis. 2006;9(3 Suppl):187-94.
PMID: 16914858
- Mosconi L, Sorbi S, de Leon MJ, Li Y, Nacmias B, Myoung PS,
Tsui W, Ginestroni A, Bessi V, Fayyazz M, Caffarra P, Pupi A.
Hypometabolism exceeds atrophy in presymptomatic early-onset
familial Alzheimer's disease.
J Nucl Med. 2006 Nov;47(11):1778-86.
PMID: 17079810
- Braak H, Rub U, Schultz C, Del Tredici K.
Vulnerability of cortical neurons to Alzheimer's and
Parkinson's diseases.
J Alzheimers Dis. 2006;9(3 Suppl):35-44. Review.
PMID: 16914843
- Stoub TR, deToledo-Morrell L, Stebbins GT, Leurgans S,
Bennett DA, Shah RC.
Hippocampal disconnection contributes to memory dysfunction
in individuals at risk for Alzheimer's disease.
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10041-5. Epub
2006 Jun 19.
PMID: 16785436
- Bouras C, Kovari E, Herrmann FR, Rivara CB, Bailey TL,
von Gunten A, Hof PR, Giannakopoulos P.
Stereologic analysis of microvascular morphology in the
elderly: Alzheimer disease pathology and cognitive status.
J Neuropathol Exp Neurol. 2006 Mar;65(3):235-44.
PMID: 16651885
- Lazarov O, Peterson LD, Peterson DA, Sisodia SS.
Expression of a familial Alzheimer's disease-linked
presenilin-1 variant enhances perforant pathway lesion-
induced neuronal loss in the entorhinal cortex.
J Neurosci. 2006 Jan 11;26(2):429-34.
PMID: 16407539
- Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H,
Honig L, Vonsattel JP, Kim TW.
Model-guided microarray implicates the retromer complex in
Alzheimer's disease.
Ann Neurol. 2005 Dec;58(6):909-19.
PMID: 16315276
- Ferrer I, Barrachina M, Puig B, Martinez de Lagran M, Marti E,
Avila J, Dierssen M.
Constitutive Dyrk1A is abnormally expressed in Alzheimer
disease, Down syndrome, Pick disease, and related transgenic
models.
Neurobiol Dis. 2005 Nov;20(2):392-400.
PMID: 16242644
- Luna-Munoz J, Garcia-Sierra F, Falcon V, Menendez I,
Chavez-Macias L, Mena R.
Regional conformational change involving phosphorylation of
tau protein at the Thr231, precedes the structural change
detected by Alz-50 antibody in Alzheimer's disease.
J Alzheimers Dis. 2005 Sep;8(1):29-41.
PMID: 16155347
- Teaktong T, Graham AJ, Court JA, Perry RH, Jaros E,
Johnson M, Hall R, Perry EK.
Nicotinic acetylcholine receptor immunohistochemistry in
Alzheimer's disease and dementia with Lewy bodies: differential
neuronal and astroglial pathology.
J Neurol Sci. 2004 Oct 15;225(1-2):39-49.
PMID: 15465084
- Duyckaerts C.
Looking for the link between plaques and tangles.
Neurobiol Aging. 2004 Jul;25(6):735-9; discussion 743-6.
Review. No abstract available.
PMID: 15165696
- Nagele RG, D'Andrea MR, Lee H, Venkataraman V, Wang HY.
Astrocytes accumulate A beta 42 and give rise to astrocytic
amyloid plaques in Alzheimer disease brains.
Brain Res. 2003 May 9;971(2):197-209.
PMID: 12706236
- Yang Y, Mufson EJ, Herrup K.
Neuronal cell death is preceded by cell cycle events at all
stages of Alzheimer's disease.
J Neurosci. 2003 Apr 1;23(7):2557-63.
PMID: 12684440
- Kobayashi K, Nakano H, Hayashi M, Shimazaki M, Fukutani Y,
Sasaki K, Sugimori K, Koshino Y.
Association of phosphorylation site of tau protein with neuronal
apoptosis in Alzheimer's disease.
J Neurol Sci. 2003 Apr 15;208(1-2):17-24.
PMID: 12639720
- Christen-Zaech S, Kraftsik R, Pillevuit O, Kiraly M, Martins R,
Khalili K, Miklossy J.
Early olfactory involvement in Alzheimer's disease.
Can J Neurol Sci. 2003 Feb;30(1):20-5.
PMID: 12619779
- Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M,
Hall R, Perry E.
Alzheimer's disease is associated with a selective increase in
alpha7 nicotinic acetylcholine receptor immunoreactivity in
astrocytes.
Glia. 2003 Jan 15;41(2):207-11.
PMID: 12509811
- Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E.
Caspase-9 activation and caspase cleavage of tau in the
Alzheimer's disease brain.
Neurobiol Dis. 2002 Nov;11(2):341-54.
PMID: 12505426
- D'Andrea MR, Nagele RG, Wang HY, Lee DH.
Consistent immunohistochemical detection of intracellular
beta-amyloid42 in pyramidal neurons of Alzheimer's disease
entorhinal cortex.
Neurosci Lett. 2002 Nov 29;333(3):163-6.
PMID: 12429373
- Holzer M, Gartner U, Stobe A, Hartig W, Gruschka H, Bruckner
MK, Arendt T.
Inverse association of Pin1 and tau accumulation in
Alzheimer's disease hippocampus.
Acta Neuropathol (Berl). 2002 Nov;104(5):471-81. Epub 2002
Jul 3.
PMID: 12410395
- Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B,
Cowburn RF.
Up-regulation of cell division cycle (cdc) 2 kinase in neurons
with early stage Alzheimer's disease neurofibrillary
degeneration.
Acta Neuropathol (Berl). 2002 Oct;104(4):369-76. Epub 2002
May 25.
PMID: 12200623
- van de Nes JA, Sandmann-Keil D, Braak H.
Interstitial cells subjacent to the entorhinal region
expressing somatostatin-28 immunoreactivity are susceptible
to development of Alzheimer's disease-related cytoskeletal
changes.
Acta Neuropathol (Berl). 2002 Oct;104(4):351-6. Epub 2002
May 22.
PMID: 12200620
- Nagele RG, D'Andrea MR, Anderson WJ, Wang HY.
Intracellular accumulation of beta-amyloid(1-42) in neurons is
facilitated by the alpha 7 nicotinic acetylcholine receptor in
Alzheimer's disease.
Neuroscience. 2002;110(2):199-211.
PMID: 11958863
- Kovacs T, Cairns NJ, Lantos PL.
Olfactory centres in Alzheimer's disease: olfactory bulb is
involved in early Braak's stages.
Neuroreport. 2001 Feb 12;12(2):285-8.
PMID: 11209936
- Nadel L.
The parahippocampal region: basic science and clinical
implications.
Hippocampus. 2000;10(2):133-5. No abstract available.
PMID: 10791834
- Thal DR, Holzer M, Rub U, Waldmann G, Gunzel S, Zedlick D,
Schober R.
Alzheimer-related tau-pathology in the perforant path target
zone and in the hippocampal stratum oriens and radiatum
correlates with onset and degree of dementia.
Exp Neurol. 2000 May;163(1):98-110.
PMID: 10785448
- Perry E, Martin-Ruiz C, Lee M, Griffiths M, Johnson M,
Piggott M, Haroutunian V, Buxbaum JD, Nasland J, Davis K,
Gotti C, Clementi F, Tzartos S, Cohen O, Soreq H, Jaros E,
Perry R, Ballard C, McKeith I, Court J.
Nicotinic receptor subtypes in human brain ageing, Alzheimer
and Lewy body diseases.
Eur J Pharmacol. 2000 Mar 30;393(1-3):215-22.
PMID: 10771016
- Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B,
Cowburn RF.
Distribution of active glycogen synthase kinase 3beta
(GSK-3beta) in brains staged for Alzheimer disease
neurofibrillary changes.
J Neuropathol Exp Neurol. 1999 Sep;58(9):1010-9.
PMID: 10499443
- Botez G, Probst A, Ipsen S, Tolnay M.
Astrocytes expressing hyperphosphorylated tau protein without
glial fibrillary tangles in argyrophilic grain disease.
Acta Neuropathol (Berl). 1999 Sep;98(3):251-6.
PMID: 10483782