PAS domain-containing protein 1 (OX-TES-1, cancer/testis antigen 63, CT63, PASD1)

Function: - may function as a transcription factor Structure: contains 1 PAS (PER-ARNT-SIM) domain Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Note=Due to intron retention Expression: - testis-specific Pathology: - found in histologically normal tissues from patients with uterine cancer , lung cancer & small intestine cancer - widespread expression seen in solid tumors & diffuse large B-cell lymphoma (DLBCL)-derived cell lines - isoform 2 is expressed in all DLBCL-derived cell lines - isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL

General

testis-specific protein transcription factor (TF)

Properties

SIZE: entity length = 773 aa MW = 87 kD COMPARTMENT: cell nucleus MOTIF: PAS domain {30-102} alanine-rich region {229-236} MOTIF: alanine residue (SEVERAL) coiled coil {365-412} lysine-rich region {508-548} MOTIF: lysine residue (SEVERAL) serine-rich region {665-668} MOTIF: serine residue (SEVERAL)

References

UniProt :accession Q8IV76