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partitioning defective 6 homolog gamma (PAR-6 gamma, PAR6D, PARD6G, PAR6G)
Function:
1) adapter protein involved in asymmetrical cell division & cell polarization processes
2) role in formation of epithelial tight junctions (putative)
3) PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins
4) interacts with PARD3 (putative)
5) interacts with GTP-bound forms of CDC42, ARHQ/TC10 & RAC1
- pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
6) interacts with the N-terminal part of PRKCI & PRKCZ
Compartment: cytoplasm
Expression:
- widely expressed
- higher expression in fetal & adult kidney
General
cytoskeletal protein
Properties
SIZE: MW = 41 kD
entity length = 376 aa
COMPARTMENT: cytoplasm
MOTIF: OPR {18-98}
binding site
SITE: 127-254
FOR-BINDING-OF: partitioning-defective 3 homolog
Cdc42
MOTIF: CRIB domain {134-151}
PDZ domain
NAME: PDZ domain
SITE: 158-251
Database Correlations
UniProt Q9BYG4
PFAM correlations
References
UniProt :accession Q9BYG4