partitioning defective 6 homolog beta (PAR-6 beta, PAR-6B, PARD6B, PAR6B)

Function: 1) adapter protein involved in asymmetrical cell division & cell polarization processes 2) role in formation of epithelial tight junctions (putative) 3) association with PARD3 may prevent interaction of PARD3 with F11R/JAM1 thus preventing tight junction assembly 4) PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins - pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases 5) interacts with GTP-bound forms of CDC42 & RAC1 6) interacts with GTP-bound ARHQ/TC10 7) interacts with MPP5 (putative) 8) interacts with the N-terminal part of PRKCI & PRKCZ 9) part of a complex with PARD3, CDC42 or RAC1 & PRKCI or PRKCZ 10) part of a complex with LLGL1 & PRKCI 11) interacts with ALS2CR19 Compartment: cytoplasm (putative) Expression: - expressed in pancreas > placenta, lung - not expressed in other tissues

Properties

SIZE: MW = 41 kD entity length = 372 aa COMPARTMENT: cytoplasm MOTIF: OPR {16-96} binding site SITE: 126-253 FOR-BINDING-OF: partitioning-defective 3 homolog Cdc42 MOTIF: CRIB domain {133-150} PDZ domain NAME: PDZ domain SITE: 157-250

Database Correlations

UniProt Q9BYG5 PFAM correlations

References

UniProt :accession Q9BYG5