partitioning defective 6 homolog alpha (PAR-6 alpha, PAR-6A, PAR-6,PAR6C, tax interaction protein 40, TIP-40, PARD6A, PAR6A)

Function: 1) adapter protein involved in asymmetrical cell division & cell polarization processes 2) formation of epithelial tight junctions (putative) 3) association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly 4) PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins - pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases 5) interacts with MAP2K5 (putative) - OPR domain mediates interactions with MAP2K5 6) interacts with PARD3 7) interacts with GTP-bound forms of CDC42, ARHQ/TC10 & RAC1 8) interacts with the N-terminal part of PRKCI & PRKCZ 9) interacts with human T-cell leukemia virus type 1 TAX protein 10) interacts with MPP5 & CRB3 11) component of complex with PARD3, CDC42 or RAC1 & PRKCI or PRKCZ 12) component of complex with LLGL1 & PRKCI Compartment: - cytoplasmic - colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles & with PARD3 & PRKCI at epithelial tight junctions Expression: - expressed in pancreas, skeletal muscle, brain, heart > kidney, placenta

Properties

SIZE: MW = 37 kD entity length = 346 aa COMPARTMENT: cytoplasm MOTIF: binding site SITE: 1-116 FOR-BINDING-OF: protein kinase C-iota protein kinase C-zeta MOTIF: OPR {15-95} binding site SITE: 126-253 FOR-BINDING-OF: partitioning-defective 3 homolog Cdc42 MOTIF: CRIB domain {133-150} PDZ domain NAME: PDZ domain SITE: 157-250

Database Correlations

OMIM 607484 UniProt Q9NPB6 PFAM correlations

References

UniProt :accession Q9NPB6