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RNA-binding protein Nova-1; neuro-oncological ventral antigen 1; onconeural ventral antigen 1; paraneoplastic Ri antigen; ventral neuron-specific protein 1 (NOVA1)
Function:
- may regulate RNA splicing or metabolism in a specific subset of developing neurons
- interacts with PTBP2; the interaction is direct
Structure:
- contains 3 KH domains
Compartment:
- nucleus
Alternative splicing:
- named isoforms=4
Expression:
- expressed in developing motor system
- expression restricted to diencephalon, brainstem, motor neurons of ventral spinal cord
Pathology:
- autoantigen in paraneoplastic opsoclonus myoclonus ataxia
Related
paraneoplastic opsoclonus myoclonus ataxia; Kinsbourne syndrome; myoclonic encephalopathy of infants; dancing eyes-dancing feet syndrome
General
neurooncologic ventral antigen (NOVA)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 510 aa
MW = 52 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {27-43}
KH domain
SITE: 49-119
FOR-BINDING-OF: ribonucleic acid
Ser phosphorylation site {S157}
KH domain
SITE: 174-240
FOR-BINDING-OF: ribonucleic acid
alanine-rich region {276-412}
MOTIF: alanine residue (SEVERAL)
KH domain
SITE: 424-491
FOR-BINDING-OF: ribonucleic acid
Database Correlations
OMIM 602157
UniProt P51513
Pfam PF00013
Entrez Gene 4857
Kegg hsa:4857
References
UniProt :accession P51513