Search
modulator of apoptosis 1; MAP-1; MAP1; paraneoplastic antigen Ma4 (MOAP1, PNMA4)
Function:
- required for death receptor-dependent apoptosis
- when associated with RASSF1, promotes BAX conformational change & translocation to mitochondrial membranes in response to TNF & TNFSF10 stimulation
- under normal circumstances, held in an inactive conformation by an intramolecular interaction
- binding to RASSF1 isoform A (RASSF1A) relieves this inhibitory interaction & allows further binding to BAX
- binds also to BCL2 & BCLX
- recruited to the TNFRSF1A & TNFRSF10A complexes in response to their respective cognate ligand, after internalization
- interacts with TRIM39
Structure:
- homodimer.
- the BH3-like domain is required for association with BAX & for mediating apoptosis
- the 3 BH domains (BH1, BH2, & BH3) of BAX are all required for mediating protein-protein interaction
- belongs to the PNMA family
Expression:
- ubiquitously expressed
- higher levels in heart & brain
Related
anti-Ma antibody
General
antigen
nuclear protein
oligomerizing protein
Properties
SIZE: entity length = 351 aa
MW = 40 kD
COMPARTMENT: cell nucleus
MOTIF: BH3-like {120-127}
binding site
SITE: 202-205
FOR-BINDING-OF: Ras association domain-containing protein 1
Database Correlations
OMIM 609485
UniProt Q96BY2
Entrez Gene 64112
Kegg hsa:64112
References
UniProt :accession Q96BY2