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paraneoplastic antigen Ma2; onconeuronal antigen Ma2; paraneoplastic neuronal antigen MM2; 40 kD neuronal protein (PNMA2, KIAA0883, MA2)
Structure: belongs to the PNMA family
Compartment: nucleus, nucleolus
Expression:
- brain specific
- specifically expressed by tumor cells in some patients with testicular cancer
Pathology:
- antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders
Related
anti-Ma antibody
General
antigen
nuclear protein
Properties
SIZE: entity length = 364 aa
MW = 42 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glutamate-rich region {333-338}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 603970
UniProt Q9UL42
Pfam PF03732
Entrez Gene 10687
Kegg hsa:10687
References
- UniProt :accession Q9UL42
- OMIM :accession 603970