Contents

Search

paraneoplastic acrokeratosis of Bazex; Bazex syndrome; acrokeratosis paraneoplastica

Etiology: - associated with squamous cell carcinoma 1) upper respiratory system (head & neck cancer) 2) esophageal cancer (squamous cell carcinoma) Pathology: * histopathology images [5] Clinical manifestations: 1) psoriaform lesions of the hands, feet, ears & nose 2) onychodystrophy 3) keratoderma may also be present - hyperkeratotic plaques on the palms & soles with surrounding erythema [3] 4) evidence of malignancy may be noted * images [3,4,5] Management: - effective treatment of the underlying malignancy results in resolution of the dermatosis

General

paraneoplastic dermatosis

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 171
  2. Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 18. American College of Physicians, Philadelphia 2009, 2012, 2018.
  3. van Leersum FS, Liu X. IMAGES IN CLINICAL MEDICINE. Acrokeratosis Paraneoplastica. N Engl J Med. 2015 Nov 26;373(22):2161 PMID: 26605930 http://www.nejm.org/doi/full/10.1056/NEJMicm1502488
  4. DermNet NZ. Acrokeratosis neoplastica (images) http://www.dermnetnz.org/systemic/acrokeratosis.html
  5. Garrity KR, James WD (images) Medscape: Acrokeratosis Paraneoplastica http://emedicine.medscape.com/article/1093193-overview