PAP-associated domain-containing protein 5 selections

PAP-associated domain-containing protein 5; topoisomerase-related function protein 4-2; TRF4-2 (PAPD5)

Function: - catalytic subunit of a TRAMP-like complex - poly(A) RNA polymerase activity - originally thought to have DNA polymerase activity - role in post-transcriptional quality control mechanism - polyadenylation with short oligo(A) tails is required for degradative activity of the exosome on several of its nuclear RNA substrates - no cofactor for polyadenylation activity needed (in vitro). - role in replication-dependent histone mRNA degradation - may be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated - may play a role in sister chromatid cohesion deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1) Cofactor: Mg⁺² or Mn+2 (putative) Structure: - belongs to the DNA polymerase type-B-like family - contains 1 PAP-associated domain Compartment: - nucleus, cytoplasm - predominantly expressed in the cytoplasm Alternative splicing: named isoforms=5 Notes: - originally thought to have DNA polymerase activity

General

DNA polymerase human longevity protein phosphoprotein

Properties

SIZE: entity length = 572 aa MW = 63 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: serine-rich region {45-76} MOTIF: serine residue (SEVERAL) manganese [Mn]-binding site SITE: 177-177 manganese [Mn]-binding site SITE: 179-179 PAP-associated {308-368} serine-rich region {447-525} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S484}

Database Correlations

OMIM 605540 UniProt Q8NDF8 PFAM correlations Entrez Gene 64282 Kegg hsa:64282

References

UniProt :accession Q8NDF8
UniProt PubMed refs - PMID: 21788334 - PMID: 21788334

Component-of

TRAMP-like complex