PAN nuclease complex

Function: - cytoplasmic mRNA decay - shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein - exonucleolytic cleavage of poly(A) to 5'-AMP

General

exoribonuclease molecular complex

Properties

MOTIF: active site SUBUNITS: PAB-dependent poly(A)-specific ribonuclease subunit 2 COMPARTMENT: cytoplasm cell nucleus MOTIF: Exonuclease {974-1147} Ser phosphorylation site {S1189} PAB-dependent poly(A)-specific ribonuclease subunit 3 COMPARTMENT: cytoplasm MOTIF: binding site SITE: 1-345 FOR-BINDING-OF: poly-A tail PAN2 interaction {346-741} MOTIF: kinase domain SITE: 346-608 MOTIF: ATP-binding site NAME: ATP-binding site

References

UniProt :accession Q504Q3

Components

PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2, inactive ubiquitin carboxyl-terminal hydrolase 52, USP52, KIAA0710, PAN2) PAB-dependent poly(A)-specific ribonuclease subunit 3 (hPan3, PAN3)