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pancreas transcription factor 1 complex (PTF1)
Function:
1) transcriptional activator
2) binds to the E-box consensus sequence 5'-CANNTG-3'
3) role in determining whether cells allocated to pancreatic buds continue towards pancreatic organogenesis or revert to duodenal development
4) maintenance of exocrine pancreas-specific gene expression including ELA1 & amylase
5) formation of pancreatic acinar & ductal cells
6) role in cerebellar development
Structure:
- components: TCF3, TCF12, PTF1A
Compartment: nucleus
General
molecular complex
Properties
SUBUNITS: transcription factor E2-alpha
COMPARTMENT: cell nucleus
MOTIF: 9aaTAD {19-27}
Ser phosphorylation site {S139}
nuclear translocation signal {170-176}
Ser phosphorylation site {S359}
Ser phosphorylation site {S379}
leucine zipper
SITE: 389-425
FOR-BINDING-VIA: leucine zipper
breakpoint {483-484}
DNA-binding motif
SITE: 546-561
helix-loop-helix
NAME: helix-loop-helix
SITE: 562-605
FOR-BINDING-VIA: helix-loop-helix
transcription factor 12
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S44}
Ser phosphorylation site {S47}
leucine zipper
SITE: 119-140
FOR-BINDING-VIA: leucine zipper
Ser phosphorylation site {S333}
DNA-binding motif
SITE: 577-589
helix-loop-helix
NAME: helix-loop-helix
SITE: 590-631
FOR-BINDING-VIA: helix-loop-helix
Class A specific {632-655}
pancreas transcription factor 1 subunit alpha
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: DNA-binding motif
SITE: 150-175
helix-loop-helix
NAME: helix-loop-helix
SITE: 176-216
FOR-BINDING-VIA: helix-loop-helix
glycine-rich region {227-248}
References
UniProt :accession Q7RTS3
Components
pancreas transcription factor 1 subunit alpha (pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, PTF1P48)
transcription factor 12; helix loop helix transcription factor-4; transcription factor HTF-4; E-box-binding protein; DNA-binding protein HTF4 (TCF12; HEB; HTF4)
transcription factor E2-alpha; class B basic helix-loop-helix protein 21; bHLHb21; immunoglobulin enhancer-binding factor E12/E47; immunoglobulin transcription factor 1; Kappa-E2-binding factor; transcription factor 3; TCF-3; transcription factor ITF-1 (TCF3, BHLHB21, E2A, ITF1)