pallidin; pallid protein homolog; syntaxin 13-interacting protein (PLDN, PA, BLOC1S6)

Function: - role in the development of lysosome-related organelles, such as melanosomes & platelet-dense granules - may play a role in intracellular vesicle trafficking, particularly in the vesicle-docking & fusion process - phosphorylated - the major soluble form is part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) - interacts with CNO/cappuccino & DTNBP1 (putative) - interacts with MUTED, syntaxin 13 & F-actin - strongly interacts with itself Compartment: - cytoplasm, endomembrane system, peripheral membrane Alternative splicing: named isoforms=3 Expression: widely expressed Pathology: - defects in PLDN are the cause of Hermansky-Pudlak syndrome type 9

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 172 aa MW = 20 kD COMPARTMENT: cytoplasm MOTIF: phosphorylation site coiled coil {63-167}

Database Correlations

OMIM correlations UniProt Q9UL45 Entrez Gene 26258 Kegg hsa:26258

References

UniProt :accession Q9UL45