paired immunoglobulin-like type 2 receptor alpha (inhibitory receptor PILR-alpha, cell surface receptor FDF03, PILRA)

Function: - paired receptors consist of highly related activating & inhibitory receptors - role in regulation of the immune system - PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases, including PTPN6/SHP-1 & PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules - interacts with PTPN6/SHP-1 & PTPN11/SHP-2 upon Tyr phosphorylation Structure: - monomer - contains 2 copies of ITIM motif - PTPN6 seems to bind predominantly to the 1st ITIM motif. - N- & O-glycosylated - phosphorylated on Tyr - contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: - isoforms 1 & 2: cell membrane - isoforms 3 & 4: secreted Alternative splicing: named isoforms=4 Expression: - predominantly detected in hemopoietic tissues - expressed by monocytes, macrophages, granulocytes, but not lymphocytes - strongly expressed by dendritic cells - preferentially expressed by CD14+/CD1a- derived from CD34+ dentritic cell progenitors - also expressed by CD11c+ blood & tonsil dentritic cells, but not by CD11c- dentritic cell precursors

Properties

SIZE: MW = 34 kD entity length = 303 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {32-150} MOTIF: N-glycosylation site {N100} transmembrane domain {198-218} immunoreceptor tyrosine-based inhibitory motif (ITIM) {267-272} immunoreceptor tyrosine-based inhibitory motif (ITIM) {296-301}

Database Correlations

OMIM 605341 UniProt Q9UKJ1 Pfam PF07686

References

UniProt :accession Q9UKJ1