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platelet-activating factor receptor; PAF-R (PTAFR PAFR)
Function:
- receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile & hypotensive activity
- seems to mediate its action via a G protein that activates a phosphatidylinositol-Ca+2 second messenger system
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression:
- expressed in the placenta, lung, left & right cardiac ventricles, heart atrium, leukocytes & differentiated HL-60 granulocytes
- induced by granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 & n-butyrate
Related
platelet-activating factor (PAF)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 342 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-16}
transmembrane domain {17-38}
cytoplasmic loop {39-54}
transmembrane domain {55-74}
exoplasmic loop {75-91}
MOTIF: cysteine residue {C90}
MODIFICATION: cysteine residue {C173}
transmembrane domain {92-113}
cytoplasmic loop {114-133}
transmembrane domain {134-155}
exoplasmic loop {156-184}
MOTIF: N-glycosylation site {N169}
cysteine residue {C173}
MODIFICATION: cysteine residue {C90}
transmembrane domain {185-205}
cytoplasmic loop {206-233}
transmembrane domain {234-254}
exoplasmic loop {255-276}
transmembrane domain {277-296}
cytoplasmic domain {297-342}
Database Correlations
OMIM 173393
UniProt P25105
Pfam PF00001
Kegg hsa:5724
References
- Barnes PJ.
Molecular biology. Inflammatory activities.
Nature. 1991 Jan 24;349(6307):284-5. No abstract available.
PMID: 1846227
- Honda Z, Nakamura M, Miki I, Minami M, Watanabe T, Seyama Y,
Okado H, Toh H, Ito K, Miyamoto T, et al.
Cloning by functional expression of platelet-activating factor
receptor from guinea-pig lung.
Nature. 1991 Jan 24;349(6307):342-6.
PMID: 1846231
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- UniProt :accession P25105