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PAF1 complex
Function:
1) multifunctional complex
2) interacts with POLR2A
3) initiation & elongation of in DNA synthesis
4) histone methylation
5) RNA processing
6) overexpression induces cell growth arrest & premature replicative senescence of fibroblasts
Structure: subunits: CDC73, PAF1, LEO1, CTR9
General
molecular complex
Properties
COMPARTMENT: cell nucleus
SUBUNITS: parafibromin
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {125-139}
RNA polymerase II-associated factor 1 homolog
COMPARTMENT: cell nucleus
MOTIF: coiled coil {352-400}
glutamate-rich region {358-452}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S456}
Ser phosphorylation site {S460}
Ser phosphorylation site {S466}
RNA polymerase-associated protein LEO1
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S151}
Ser phosphorylation site {S154}
Ser phosphorylation site {S162}
Ser phosphorylation site {S171}
Ser phosphorylation site {S179}
Ser phosphorylation site {S279}
Ser phosphorylation site {S630}
Ser phosphorylation site {S658}
RNA polymerase-associated protein CTR9 homolog
COMPARTMENT: cell nucleus
MOTIF: tetratricopeptide repeat {41-75}
tetratricopeptide repeat {129-162}
tetratricopeptide repeat {163-196}
tetratricopeptide repeat {198-231}
tetratricopeptide repeat {235-268}
tetratricopeptide repeat {306-339}
tetratricopeptide repeat {341-374}
tetratricopeptide repeat {412-444}
tetratricopeptide repeat {451-484}
tetratricopeptide repeat {497-530}
tetratricopeptide repeat {531-564}
tetratricopeptide repeat {566-598}
tetratricopeptide repeat {613-646}
tetratricopeptide repeat {647-680}
tetratricopeptide repeat {681-714}
tetratricopeptide repeat {717-750}
lysine-rich region {844-1011}
MOTIF: lysine residue (SEVERAL)
glycine-rich region {904-908}
Thr phosphorylation site {T925}
lysine-rich region {933-936}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S941}
Ser phosphorylation site {S943}
lysine-rich region {956-959}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S970}
serine-rich region {1015-1172}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1015}
Ser phosphorylation site {S1016}
Ser phosphorylation site {S1017}
Ser phosphorylation site {S1020}
Ser phosphorylation site {S1021}
References
UniProt :accession Q8WVC0
Components
parafibromin; hyperparathyroidism 2 protein; cell division cycle protein 73 homolog (CDC73, C1orf28, HRPT2)
RNA polymerase II-associated factor 1 homolog (hPAF1, pancreatic differentiation protein 2, PAF1, PD2)
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1, CTR9, KIAA0155, SH2BP1)
RNA polymerase-associated protein LEO1 (replicative senescence down-regulated leo1-like protein, LEO1, RDL)