pituitary adenylate cyclase-activating polypeptide type 1 receptor; PACAP type I receptor; PACAP-R-1 (ADCYAP1R1)

Function: - receptor for PACAP-27 & PACAP-38. - activity is mediated by G proteins which activate adenylyl cyclase - may regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, & other catecholamines - may play a role in spermatogenesis & sperm motility - causes smooth muscle relaxation & secretion in the gastrointestinal tract Structure: belongs to the G-protein coupled receptor 2 family Compartment: cell membrane; multi-pass membrane protein Expression: - most abundant in the brain - low expression in the lung, liver, thymus, spleen, pancreas & placenta

General

glycoprotein pituitary adenyl cyclase activating polypeptide [PACAP] receptor

Properties

SIZE: entity length = 468 aa MW = 53 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} exoplasmic domain {21-155} MOTIF: N-glycosylation site {N48} N-glycosylation site {N60} N-glycosylation site {N117} transmembrane domain {156-178} cytoplasmic loop {179-186} transmembrane domain {187-205} exoplasmic loop {206-227} transmembrane domain {228-253} cytoplasmic loop {254-268} transmembrane domain {269-291} exoplasmic loop {292-309} MOTIF: N-glycosylation site {N300} transmembrane domain {310-332} cytoplasmic loop {333-350} transmembrane domain {351-371} exoplasmic loop {372-385} MOTIF: N-glycosylation site {N375} transmembrane domain {386-405} cytoplasmic domain {406-468}

Database Correlations

OMIM 102981 UniProt P41586 PFAM correlations Kegg hsa:117

References

UniProt :accession P41586