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CD271; p75 NGFR; tumor necrosis factor receptor superfamily member 16; low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; low affinity neurotrophin receptor p75NTR (NGFR, TNFRSF16)

Function: - low affinity NGF receptor - can bind to NGF, BDNF, NT-3, & NT-4 - can mediate cell survival as well as cell death of neural cells - phosphorylated on Ser - interacts with p75NTR-associated cell death executor - interacts with TRAF2, TRAF4, TRAF6, PTPN13 & RANBP9 - interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 - interacts with BEX1 & NGFRAP1/BEX3 - interacts with ARMS & NTRK1 - can form a ternary complex with NTRK1 & ARMS; this complex is affected by the expression of ARMS; an increase in ARMS expression leads to a decreased association of NGFR & NTRK1 (putative) - interacts with LINGO1 Structure: - N- & O-glycosylated - O-linked glycans consist of gal(1-3)galNAc core elongated by 1 or 2 neuNAc - homodimer, disulfide-linked - Death domain is responsible for interaction with RANBP9 - the extracellular domain is responsible for interaction with NTRK1 (putative) - contains 1 death domain - contains 4 TNFR-Cys repeats Compartment: membrane

Interactions

molecular events

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein phosphoprotein tumor necrosis factor [TNF] receptor family

Properties

SIZE: entity length = 427 aa MW = 45 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-28} TNFR-Cys {31-64} MOTIF: cysteine residue {C32} MODIFICATION: cysteine residue {C43} cysteine residue {C43} MODIFICATION: cysteine residue {C32} cysteine residue {C44} MODIFICATION: cysteine residue {C57} cysteine residue {C47} MODIFICATION: cysteine residue {C64} cysteine residue {C57} MODIFICATION: cysteine residue {C44} N-glycosylation site {N60} cysteine residue {C64} MODIFICATION: cysteine residue {C47} TNFR-Cys {66-107} MOTIF: cysteine residue {C67} MODIFICATION: cysteine residue {C83} cysteine residue {C83} MODIFICATION: cysteine residue {C67} cysteine residue {C86} MODIFICATION: cysteine residue {C99} cysteine residue {C89} MODIFICATION: cysteine residue {C107} cysteine residue {C99} MODIFICATION: cysteine residue {C86} cysteine residue {C107} MODIFICATION: cysteine residue {C89} TNFR-Cys {108-146} MOTIF: cysteine residue {C109} MODIFICATION: cysteine residue {C122} cysteine residue {C122} MODIFICATION: cysteine residue {C109} cysteine residue {C125} MODIFICATION: cysteine residue {C138} cysteine residue {C128} MODIFICATION: cysteine residue {C146} cysteine residue {C138} MODIFICATION: cysteine residue {C125} cysteine residue {C146} MODIFICATION: cysteine residue {C128} TNFR-Cys {148-188} MOTIF: cysteine residue {C149} MODIFICATION: cysteine residue {C164} cysteine residue {C164} MODIFICATION: cysteine residue {C149} cysteine residue {C167} MODIFICATION: cysteine residue {C180} cysteine residue {C170} MODIFICATION: cysteine residue {C188} cysteine residue {C180} MODIFICATION: cysteine residue {C167} cysteine residue {C188} MODIFICATION: cysteine residue {C170} threonine-rich region {197-248} MOTIF: threonine residue (SEVERAL) transmembrane domain {251-272} Mediates interaction with ARMS {326-341} death domain NAME: death domain SITE: 344-421 MISC-INFO: Kd [NGF] 1 NM

Database Correlations

OMIM 162010 UniProt P08138 PFAM correlations Kegg hsa:4804

References

  1. UniProt :accession P08138
  2. Smith et al Science 248:1019 1991 - Smith CJ, Wion D, Brachet P. Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line. Brain Res Mol Brain Res. 1991 Jul;10(4):351-4. PMID: 1656161
  3. Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: 2053133
  4. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8. PMID: 1850549

Component-of

nerve growth factor [NGF] receptor (high affinity)