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TP53-regulating kinase; Nori-2; p53-related protein kinase (TP53RK, C20orf64, PRPK)
Function:
- protein kinase that phosphorylates Ser-15 of p53/TP53 protein & may therefore participate in its activation
- interacts with TPRKB
ATP + a protein = ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily
- contains 1 protein kinase domain
Compartment: nucleus
Expression:
- expressed in testis > heart, kidney, spleen
General
nuclear protein
phosphoprotein
serine/threonine kinase
Properties
SIZE: entity length = 253 aa
MW = 28 kD
COMPARTMENT: cell nucleus
STATE: active state
MOTIF: Thr phosphorylation site {T7}
Thr phosphorylation site {T8}
kinase domain
SITE: 33-253
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 39-47
Ser phosphorylation site {S34}
ATP-binding site
NAME: ATP-binding site
SITE: 60-60
nuclear translocation signal {78-95}
Thr phosphorylation site {T129}
Thr phosphorylation site {T132}
Thr phosphorylation site {T135}
Ser phosphorylation site {S140}
aspartate residue {D162}
Tyr phosphorylation site {Y201}
Database Correlations
OMIM 608679
UniProt Q96S44
Pfam PF06293
Entrez Gene 112858
Kegg hsa:112858
ENZYME 2.7.11.1
References
UniProt :accession Q96S44