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quinone oxidoreductase PIG3; tumor protein p53-inducible protein 3; p53-induced gene 3 protein (TP53I3, PIG3)
Function:
- may be involved in generation of reactive oxygen species (ROS)
- low NADPH-dependent naphtoquinone reductase activity, with a preference for 1,2-naphtoquinone over 1,4-naphtoquinone
- has low NADPH-dependent diamine reductase activity (in vitro)
Kinetic parameters:
- KM=215 uM for 1,2-naphtoquinone
Structure:
- homodimer
- belongs to the Zn+2-containing alcohol dehydrogenase family, quinone oxidoreductase subfamily
Alternative splicing:
- named isoforms=2
- isoform 1: major isoform under normal light conditions
- isoform 2:
- UV radiation favors the production of isoform 2
- rapid proteolytic degradation by the proteasome
Expression:
- isoform 1 & isoform 2 are both activated by TP53/p53, doxorubicin, etoposide & ionizing radiation
- isoform 2 is highly activated by UV radiation
General
apoptosis stimulating protein of p53; p53-binding protein (ASPP)
quinone reductase
Properties
SIZE: entity length = 332 aa
MW = 36 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
cofactor-binding site [41-41]
COFACTOR-BOUND: NADP
cofactor-binding site [148-154]
COFACTOR-BOUND: NADP
phosphorylation site
cofactor-binding site [173-177]
COFACTOR-BOUND: NADP
cofactor-binding site [192-192]
COFACTOR-BOUND: NADP
cofactor-binding site [264-266]
COFACTOR-BOUND: NADP
cofactor-binding site [322-322]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 605171
UniProt Q53FA7
PFAM correlations
Entrez Gene 9540
Kegg hsa:9540
References
- UniProt :accession Q53FA7
- NIEHS-SNPs
http://egp.gs.washington.edu/data/tp53i3/
- OMIM :accession 605171