p53 family protein

Function: - p63 & p73 have essential roles in development - p53, p63 & p73 affect transcriptional activity & apoptosis - p53 has role in tumor suppression, is activated by cellular stress signals, inactivated by oncogenic viruses & degraded by mdm2.

Specific

cellular tumor antigen p53; tumor suppressor p53, phosphoprotein p53; antigen NY-CO-13 (TP53, p53) p51 protein p63 protein; p53 homolog p63; tumor protein p73-like; p73L; TP63; p51; p40; keratinocyte transcription factor KET; chronic ulcerative stomatitis protein (CUSP, TP73L, KET, p63, P73H) tumor protein p73; p53-like transcription factor; p53-related protein (TP73, p73)

General

DNA-binding protein oligomerizing protein transcription factor (TF)

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif

References

- Lohrum MA and Vousden JH. Regulation and function of the p53-related proteins: same family, different rules Trends in Cell Biology 10:197-202 2000 PMID: 10754563