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52 kD Ro protein; Sjoegren syndrome type A antigen; SS-A; Ro(SS-A); 52 kD ribonucleoprotein autoantigen Ro/SS-A; tripartite motif-containing protein 21; RING finger protein 81 (TRIM21, RNF81, Ro52, SSA1)
Function:
- component of a ribonucleoprotein particle composed of a single polypeptide & one of four small RNA molecules (Y-RNA)
- in the free state, Ro binds to a variety of misfolded RNAs including misfolded 5S rRNAs, & is thought to act as some sort of quality control mechanism
- Y RNA appears to function as a repressor of Ro
Structure:
- belongs to the TRIM/RBCC family
- contains 1 B box-type Zn+2 finger
- contains 1 B30.2/SPRY domain
- contains 1 RING-type Zn+2 finger
Compartment: cytoplasm. nucleus
Expression:
- present in all mammalian cells studied
- tissue specific differences in RO/SSA proteins have been identified
Pathology:
- sera from patients with systemic lupus erythematosus (SLE) or primary Sjoegren syndrome often contain antibodies that react with normal cellular RO protein as if this antigen was foreign
Related
Sjogren syndrome type A antigen (SSA/Ro)
Sjogren's syndrome (autoimmune epitheliitis)
SSA/Ro Ab in serum
General
antigen
DNA-binding protein
phosphoprotein
ribonucleoprotein
ring finger protein
RNA-binding protein
Properties
SIZE: entity length = 475 aa
MW = 54 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {16-55}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 92-123
EFFECTOR-BOUND: Zn+2
coiled coil {128-238}
Ser phosphorylation site {S266}
B30.2/SPRY {268-465}
Database Correlations
OMIM 109092
UniProt P19474
PFAM correlations
Entrez Gene 6737
Kegg hsa:6737
References
UniProt :accession P19474