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FK506-binding protein 5 (51 kD FK506-binding protein, 54 kD progesterone receptor-associated immunophilin, FKBP54, FF1 antigen, HSP90-binding immunophilin, androgen-regulated protein 6, FKBP5)
Function:
- interacts with functionally mature hetero-oligomeric progesterone receptor complexes along with HSP90 & TEBP
- part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 & steroid receptors
- dissociates from the complex when NR3C1 binds glucocorticoid
- inhibited by FK506 but not cyclosporin
- phosphorylated upon DNA damage, probably by ATM or ATR
peptidylproline (omega=180) peptidylproline (omega=0)
Structure:
- contains 2 PPIase FKBP-type domains
- contains 3 TPR repeats
Compartment: cytoplasm. nucleus
Expression:
- widely expressed
- enriched in testis compared to other tissues
- induced by androgen
Pathology:
- elevated expression of FKBP5 protein promotes inflammation [2]
- aging, stress, & depression increase expression of FKBP5 [2]
- increased expression of FKBP5 increases expression of NF-kappa B [2]
General
FK506 binding protein (FKBP)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 457 aa
MW = 51 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S13}
active site
SITE: 42-130
active site
SITE: 157-243
tetratricopeptide repeat {268-301}
tetratricopeptide repeat {317-350}
tetratricopeptide repeat {351-384}
Ser phosphorylation site {S445}
Database Correlations
OMIM 602623
MORBIDMAP 602623
UniProt Q13451
PFAM correlations
ENZYME 5.2.1.8
References
- UniProt :accession Q13451
- Zannas AS, Jia M, Hafner K et al.
Epigenetic upregulation of FKBP5 by aging and stress contributes to
NF-kappa-B driven inflammation and cardiovascular risk.
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11370-11379.
PMID: 31113877 Free PMC Article
https://www.pnas.org/content/116/23/11370