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regulator of chromosome condensation; chromosome condensation protein 1; cell cycle regulatory protein (RCC1, CHC1)
Function:
- ran protein guanine nucleotide exchange factor; promotes the exchange of Ran-bound GDP by GTP
- RCC1/Ran complex (together with other proteins) acts as a component of a signaling pathway that detects unreplicated DNA
- role in regulation of chromosome condendation in S phase
- required for initiation of DNA synthesis & for progression through the cell cycle
- role in nucleocytoplasmic & intranuclear transport of ribonucleoprotein (RNP) particles
- GTP hydrolysis of TC4-GTP promotes deposition of RNP's at targeted sites such as nuclear pore complexes or nucleoli
Structure: contains 7 RCC1 repeats
Compartment:
- nucleus, cytoplasm
- becomes dispersed throughout the cytoplasm during mitosis
Pathology:
- patients with Raynaud's syndrome produce antibodies that recognize p46RCC1
Comparative biology:
- the pim1 gene in Saccharomyces pombe is a homolog of RCC1; the product of the yeast gene is a serine/threonine kinase implicated in coupling S -> M phase transition in the cell cycle
- there is also a mammalian pim-1 gene which encodes a cytoplasmic serine/threonine kinase
Related
RCC1 gene
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 421 aa
MW = 45 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S11}
RCC1 repeat {34-84}
RCC1 repeat {85-136}
RCC1 repeat {138-189}
RCC1 repeat {191-257}
RCC1 repeat {258-311}
RCC1 repeat {312-362}
RCC1 repeat {363-416}
MOTIF: Ser phosphorylation site {S403}
Ser phosphorylation site {S405}
Ser phosphorylation site {S406}
Thr phosphorylation site {T411}
Database Correlations
OMIM 179710
UniProt P18754
Pfam PF00415
LOCUS-LINK correlations
Kegg hsa:751867
References
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209
- Cheng Y et al
Diverse effects of the guanine nucleotide exchange factor RCC1
on RNA transport.
Science 267:1807 1995
PMID: 7534442