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neutrophil cytosol factor 4 (NCF-4, neutrophil NADPH oxidase factor 4, p40-phox, p40phox, NCF4)
Function:
1) component of the NADPH-oxidase
2) assembly &/oractivation of NADPH-oxidase complex.
3) associates primarily with p67phox
Alternative splicing: named isoforms=2
Expression: restricted to hematopoietic cells
General
phosphoprotein
protein subunit
Properties
SIZE: MW = 40 kD
COMPARTMENT: cytoplasm
CELL: neutrophil
T-cell
B lymphocyte
MOTIF: PX domain {19-140}
MOTIF: SH3-binding site
NAME: SH3-binding site
Thr phosphorylation site {T154}
src homology 3 [SH3] domain
SITE: 170-229
Ser phosphorylation site {S315}
Database Correlations
OMIM 601488
UniProt Q15080
PFAM correlations
References
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995
PMID: 7531822
- UniProt :accession Q15080
Component-of
NADPH oxidase