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transcription initiation factor TFIID subunit 9; RNA polymerase II TBP-associated factor subunit G; STAF31/32; transcription initiation factor TFIID 31 kD subunit; TAFII-31; TAFII31; transcription initiation factor TFIID 32 kD subunit; TAFII-32; TAFII32 (TAF9, TAF2G, TAFII31)
Function:
- component of TFIID complex, TFTC-HAT complex, PCAF complex & the STAGA complex
- essential for cell viability
- TAF9 & TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes
- may have a role in gene regulation associated with apoptosis
- binds N-terminal domain of TP53/p53, essential for transcription
- binds TFIIB & the Herpes simplex virus activator VP16
- forms a heterodimer with TAF6/TAFII80 in a complex with the TAF4B/TAFII105-TAF12/TAFII20 heterodimer
- also interacts with TAF5
- binds directly DNA with increased DNA binding when complexed with TAF6/TAFII80
Structure: belongs to the TAF9 family
Compartment: nucleus
Expression: 6 to 8-fold by apoptotic signals
Related
adenylate kinase isoenzyme 6; ATP-AMP transphosphorylase 6; coilin-interacting nuclear ATPase protein; hCINAP (TAF9, AK6, CINAP, AD-004, CGI-137)
General
DNA-binding protein
phosphoprotein
transcription factor IID subunit
Properties
SIZE: entity length = 264 aa
MW = 29 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S85}
DNA-binding motif
SITE: 120-137
Ser phosphorylation site {S149}
Ser phosphorylation site {S155}
Ser phosphorylation site {S158}
Thr phosphorylation site {T159}
Thr phosphorylation site {T161}
Thr phosphorylation site {T178}
Ser phosphorylation site {S181}
Database Correlations
OMIM 600822
UniProt Q16594
Pfam PF02291
Entrez Gene 6880
References
- UniProt :accession Q16594
- NIEHS-SNPs
http://egp.gs.washington.edu/data/taf9/
Component-of
PCAF complex; coactivator for p53/TP53-dependent transcriptional activation; PCAF histone acetylase complex