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P2Y9 purinoceptor; lysophosphatidic acid receptor 4; LPA receptor 4; LPA-4; P2Y purinoceptor 9; P2Y9; purinergic receptor 9; G-protein coupled receptor 23; P2Y5-like receptor (LPAR4, GPR23, LPA4, P2RY9)
Function:
- receptor for lysophosphatidic acid (LPA)
- transduces a signal by increasing intracellular Ca+2 & by stimulating adenylyl cyclase activity
- potency for agonists is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- high expression in ovary
- not detected in brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus or hippocampus
General
glycoprotein
lysophosphatidic acid receptor (LPA-R)
P2Y purinoceptor or P2Y purinergic receptor
Properties
SIZE: entity length = 370 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-43}
MOTIF: N-glycosylation site {N15}
N-glycosylation site {N24}
N-glycosylation site {N28}
transmembrane domain {44-64}
cytoplasmic loop {65-73}
transmembrane domain {74-94}
exoplasmic loop {95-112}
MOTIF: cysteine residue {C111}
MODIFICATION: cysteine residue {C188}
transmembrane domain {113-133}
cytoplasmic loop {134-155}
transmembrane domain {156-176}
exoplasmic loop {177-203}
MOTIF: N-glycosylation site {N183}
cysteine residue {C188}
MODIFICATION: cysteine residue {C111}
transmembrane domain {204-224}
cytoplasmic loop {225-254}
transmembrane domain {255-275}
exoplasmic loop {276-294}
transmembrane domain {295-315}
cytoplasmic domain {316-370}
Database Correlations
OMIM 300086
UniProt Q99677
Pfam PF00001
Entrez Gene 2846
Kegg hsa:2846
References
UniProt :accession Q99677