P2Y5 purinoceptor; oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; purinergic receptor 5; RB intron encoded G-protein coupled receptor (P2RY5, LPAR6)

Function: - binds to oleoyl-L-alpha-lysophosphatidic acid (LPA) - intracellular cAMP is involved in the receptor activation - important for the maintenance of hair growth & texture Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane; multi-pass membrane protein Expression: - expressed ubiquitously, including in skin & hair follicle cells - detected in both Henle's & Huxley's layers of the inner root sheath of the hair follicle & in suprabasal layers of the epidermis (at protein level) - expressed at low levels in peripheral blood leukocytes - markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway - not detectable in undifferentiated HL60 cells - only low levels after the induction of differentiation along the granulocytic pathway Pathology: - defects in P2RY5 are a cause of: a) autosomal recessive woolly hair b) localized autosomal recessive hypotrichosis type 3 Genetics: - gene is nested within intron 17 of the retinoblastoma gene

General

glycoprotein P2Y purinoceptor or P2Y purinergic receptor

Properties

SIZE: entity length = 344 aa MW = 39 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-19} MOTIF: N-glycosylation site {N5} transmembrane domain {20-46} cytoplasmic loop {47-55} transmembrane domain {56-79} exoplasmic loop {80-92} MOTIF: cysteine residue {C89} MODIFICATION: cysteine residue {C168} transmembrane domain {93-112} cytoplasmic loop {113-133} transmembrane domain {134-154} exoplasmic loop {155-181} MOTIF: cysteine residue {C168} MODIFICATION: cysteine residue {C89} transmembrane domain {182-209} cytoplasmic loop {210-227} transmembrane domain {228-253} exoplasmic loop {254-272} transmembrane domain {273-292} MOTIF: cysteine residue {C284} MODIFICATION: palmitate COMPARTMENT: membrane cytoplasmic domain {293-344}

Database Correlations

OMIM correlations MORBIDMAP 609239 UniProt P43657 Pfam PF00001 Kegg hsa:1016

References

UniProt :accession P43657