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P2U/P2Y2 purinoceptor; P2Y purinoceptor 2; P2U purinoceptor 1 (P2RY2, P2RU1, P2Y2, P2U1)
Function:
- receptor for ATP & UTP
- coupled to G-proteins that activate phosphatidylinositol-Ca+2 second messenger system
- affinity is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression: spleen, testis, kidney, liver, lung, heart & brain
General
glycoprotein
P2Y purinoceptor or P2Y purinergic receptor
Properties
SIZE: entity length = 377 aa
MW = 42 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-32}
MOTIF: N-glycosylation site {N9}
N-glycosylation site {N13}
transmembrane domain {33-59}
cytoplasmic loop {60-70}
transmembrane domain {71-93}
exoplasmic loop {94-110}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C183}
transmembrane domain {111-129}
cytoplasmic loop {130-152}
transmembrane domain {153-172}
exoplasmic loop {173-194}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C106}
transmembrane domain {195-220}
cytoplasmic loop {221-246}
transmembrane domain {247-269}
exoplasmic loop {270-287}
transmembrane domain {288-309}
cytoplasmic domain {310-377}
Database Correlations
OMIM 600041
UniProt P41231
Pfam PF00001
Entrez Gene 5029
Kegg hsa:5029
References
UniProt :accession P41231