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P2X7 purinoceptor; P2X purinoceptor 7; P2X7; ligand-gated ion channel purinergic receptor P2X7; P2Z receptor (P2RX7)
Function:
- receptor for ATP
- acts as a ligand gated ion channel
- role in ATP-dependent lysis of macrophages via formation of membrane pores permeable to large molecules
- may function in both fast synaptic transmission & ATP-mediated lysis of antigen-presenting cells
- interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 & PTPRB
- phosphorylation results in its inactivation
Structure:
- belongs to the P2X receptor family
- forms homo- or heteropolymers
Compartment: membrane
General
glycoprotein
P2X purinoceptor or P2X purinergic receptor
phosphoprotein
transmembrane 2 protein
Properties
SIZE: entity length = 595 aa
MW = 69 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-25}
transmembrane domain {26-46}
exoplasmic loop {47-334}
MOTIF: N-glycosylation site {N187}
N-glycosylation site {N202}
N-glycosylation site {N213}
N-glycosylation site {N241}
N-glycosylation site {N284}
transmembrane domain {335-355}
MOTIF: Tyr phosphorylation site {Y343}
cytoplasmic domain {356-595}
Database Correlations
OMIM 602566
UniProt Q99572
Pfam PF00864
Entrez Gene 5027
Kegg hsa:5027
References
- UniProt :accession Q99572
- Wikipedia; Note: P2X receptor entry
http://en.wikipedia.org/wiki/P2X_receptor
- Wikipedia; Note: P2RX7 entry
http://en.wikipedia.org/wiki/P2RX7