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FK506-binding protein 3, 25 kD FK506-binding protein or rapamycin-selective 25 kD immunophilin

Function: - FK506- & rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways - PPIases accelerate the folding of proteins - inhibited preferentially by rapamycin over FK506 Peptidylproline (omega=180) peptidylproline (omega=0) Structure: - belongs to the FKBP-type PPIase family - contains 1 PPIase FKBP-type domain Compartment: nucleus

General

FK506 binding protein (FKBP) nuclear protein

Properties

SIZE: MW = 25 kD COMPARTMENT: cell nucleus MOTIF: active site binding site FOR-BINDING-OF: sirolimus

Database Correlations

OMIM 186947 UniProt Q00688 ENZYME 5.2.1.8

References

  1. UniProt :accession Q00688
  2. Martinus RD et al Role of chaperones in the biogenesis and maintenance of the mitochondrion. FASEB J. 1995 Mar;9(5):371-8. Review. PMID: 7896006