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p21-activated protein kinase-interacting protein 1; PAK1-interacting protein 1; PAK/PLC-interacting protein 1; hPIP1 (PAK1IP1, PIP1, WDR84)
Function:
- negatively regulates PAK1 kinase
- binds to the N-terminus of PAK1
- inhibits specific activation of PAK1 kinase by CDC42
Structure: contains 5 WD repeats
Compartment: nuclear, nucleolar
Expression:
- widely expressed
- expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen & thymus
General
nuclear protein
phosphoprotein
WD repeat protein family
Properties
SIZE: entity length = 392 aa
MW = 44 kD
COMPARTMENT: cell nucleus
MOTIF: WD repeat {40-77}
WD repeat {80-118}
WD repeat {121-160}
WD repeat {202-240}
WD repeat {243-284}
Ser phosphorylation site {S320}
Ser phosphorylation site {S323}
Database Correlations
OMIM 607811
UniProt Q9NWT1
Pfam PF00400
Entrez Gene 55003
Kegg hsa:55003
References
UniProt :accession Q9NWT1